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Stochastic Approaches for Systems Biology


This textbook focuses on stochastic analysis in  systems biology  containing both the theory and application. While the authors provide a review of probability and random variables, subsequent notions of biochemical reaction systems and the relevant concepts of probability theory are introduced side by side. This leads to an intuitive and easy-to-follow presentation of stochastic framework for modeling subcellular biochemical systems. In particular, the authors make an effort to show how the notion of propensity, the chemical master equation and the stochastic simulation algorithm arise as consequences of the Markov property.   The text contains many  illustrations, examples and exercises to illustrate the ideas and methods that are introduced. Matlab code is also provided where appropriate. Additionally, the cell cycle is  introduced as a more complex case study.   Senior undergraduate and graduate students in mathematics and physics as well as researchers  working in the area of systems biology, bioinformatics and related areas will find this text useful.

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