Used extensively in cellular and molecular biology research and cytogenetic applications, nucleotide analogs are currently available for the treatment of various diseases. Nucleoside Triphosphate and Their Analogs: Chemistry, Biotechnology, and Biological Applications features the contributions of 18 scientists from both academia and industry in the first complete source dedicated entirely to nucleoside triphosphate (NTP). The text provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP alongside their application in life sciences.
This book examines the structural components of NTPs' diverse
biological properties and therapeutic consequences, including
cytotoxic compounds, antiviral agents, and immunosuppressive
molecules. The text describes synthetic methods used for all types
of nucleotides and reviews families of enzymes that depend on
nucleotides for assembling DNA and RNA molecules. This book also
emphasizes the key role NTP plays in the global tracking of
conformational changes in nucleic acids and nucleic acid complexes
and the investigation of cellular processes and genetic material.
The author details the pharmaceutical and diagnostic applications
of NTP modification and how fluorescent labeled nucleotide analogs
provide sensitive probes for studying the structure, dynamics, and
interactions of nucleic acids.
Nucleoside Triphosphate and Their Analogs: Chemistry,
Biotechnology, and Biological Applications discusses the potential
of current applications and future research into context with an
in-depth analysis of the role anticancer and antiviral nucleoside
analogs play in medical treatments, including antiretroviral
therapy regimens (for the treatment of HIV), anti-rejection therapy
for organ transplants, hematological malignancy therapy, and the
treatment of nonmalignant disorders, solid tumors, immunologic
diseases, and multiple sclerosis.