Chronic kidney disease is one of the world’s major public health
problems, and the prevalence of kidney failure is rising steadily.
Among the risk factors for a faster progression of renal disease
are hypertension and proteinuria, many studies clearly
demonstrating that hypertension is both a cause and consequence of
chronic kidney disease. Namely, renal blood pressure regulation
seems to be involved in five major pathophysiological mechanisms
(all closely related to the renin-angiotensin system):
Pressure-natriuresis, renal sympathetic nervous system, renal blood
flow, intraglomerular pressure and tubuloglomerular feedback. This
book reviews experimental data which form the basis of our current
understanding of the association between hypertension and kidney
diseases: The pathogenesis of increased blood pressure, the
mechanisms by which systemic hypertension promotes progressive
kidney failure, and the impact of antihypertensive agents on
experimental renal mechanisms involved in hypertension.
Furthermore, the role of angiotensin II receptor blockers in both
the control of systemic blood pressure and the reduction of
proteinuria is examined in an attempt to define optimal therapeutic
strategies to prevent the otherwise inexorable deterioration of
renal function in patients with chronic kidney disease.