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Showing: 1-10 results of 774

A valuable guide to understanding the problem of quantifying uncertainty in dose response relations for toxic substances In today's scientific research, there exists the need to address the topic of uncertainty as it pertains to dose response modeling. Uncertainty Modeling in Dose Response is the first book of its kind to implement and compare different methods for quantifying the uncertainty in the probability of response, as a function... more...

 A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in... more...

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell... more...

The dramatic story of the Flint water crisis, told “with the gripping intrigue of a Grisham thriller” (O: The Oprah Magazine)—an inspiring tale of scientific resistance by a relentless physician who stood up to power. Flint was already a troubled city in 2014 when the state of Michigan—in the name of austerity—shifted the source of its water supply from Lake Huron to the Flint River. Soon after, citizens began complaining about the water... more...

This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for submission to both agencies. It also provides practical study designs and approaches that can be used to meet... more...


Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein... more...

Persistent Organic Pollutants (POPs) continue to be the subject of concern amongst the public, as well as the scientific and policy-making communities. These concerns are exemplified by the international efforts co-ordinated by the United Nations' Environment Programme and the +Economic Commission for Europe. Whilst the ultimate origin of this concern is the adverse effects of persistent organic pollutants in both humans and wildlife, there are other... more...

The Handbook of Ecotoxicology provides a readily accessible, yet critical collection of information on ecotoxicological testing. Now available in a single paperback volume, this handbook represents excellent value. Part A concentrates on techniques, especially those tests used for prediction. Thorough descriptions of the main tests are provided, followed by critical analyses in terms of ease of handling, repeatability and ecological relevance, and... more...

The Committee on Dosimetry for the Radiation Effects Research Foundation (RERF) was set up more than a decade ago at the request of the U.S. Department of Energy. It was charged with monitoring work and experimental results related to the Dosimetry System 1986 (DS86) used by RERF to reconstruct the radiation doses to the survivors in Hiroshima and Nagasaki. At the time it was established, DS86 was believed to be the best available... more...