Pui-Yan Kwok, MD, PhD, has assembled a comprehensive collection of
readily reproducible techniques for the difficult process of single
nucleotide polymorphisms (SNP) discovery and genotyping. These
cutting-edge protocols for mutation/SNP detection utilize
denaturing high-performance liquid chromatography (dHPLC),
single-strand conformation polymorphism (SSCP),
conformation-sensitive gel electrophoresis (CSGE), chemical
cleavage, and direct sequencing.... more...