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Showing: 1-10 results of 1634

After I came to know Jerne's network theory on the immune system, I became fascinated with the immune system as an information system. The main pro­ totypes for biological information systems have been the neural systems and the brain. However, the immune system is not only an interesting informa­ tion system but it may provide a design paradigm for artificial information systems. With such a consideration, I initiated a project titled "autonomous... more...

In 1996 the International Committee for Taxonomy of Viruses (ICTV) recognized the name Nidovirales, as the formal name for Coronaviridae and A rteriviridae. In recognition of this change, and in response to the wishes of our colleagues we named this meeting for the first time "The International Symposium of Nidoviruses". The meeting in the wooded environment of Lake Harmony, Pennsylvania, provided a stimulating opportunity for assessing the progress... more...

Infectious diseases are an important cause of malnutrition. Recurrent infections increase the risk of malnutrition while poor nutritional status results in lowered immune status and predisposes to infectious disease thus propagating the vicious cycle of infection and malnutrition. The nutrition-infection-immunity axis is crucial for both developed and developing countries and is now a central feature of many nutrition and infectious disease courses.... more...

This work is concerned with a group of proteins which were originally consid­ ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen­ sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided... more...

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and... more...


Retroviruses arguably belong to the most fascinating of all viruses because of their unusual and highly efficient mode of replication involving reverse transcription and integration of the viral genome and a complex system of transcriptional and post­ transcriptional regulatory mechanisms. The importance of ret­ roviruses as human and animal pathogens has also enhanced scientific and medical interest in this diverse group of viruses and has spurred... more...

The biological bases of invertebrate immune responses have interested scientists for decades, from the first relevant observation by E. Metchnikoff in 1882, who discovered phagocytosis while studying starfish larvae. Invertebrate immunology first began to be appre­ ciated as an important field in the late 1960s and 1970s. However, in the following years there was much controversy regarding the question: do invertebrates offer insight into the origin... more...

"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical... more...

Allergic skin diseases belong to the most common dermatoses. This book deals with fundamental (in particular immunological aspects) as well as clinical symptoms and therapeutic strategies of the allergic skin diseases. Cells involved in the pathomechanisms of allergic skin disease are described in individual chapters. The allergic skin diseases which will be discussed are atopic dermatitis, being the chronic inflammatory skin disease with the highest... more...

Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The... more...